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Гелданамицин
- английское имяGeldanamycin
- CAS №30562-34-6
- CBNumberCB8462842
- ФормулаC29H40N2O9
- мольный вес560.64
- EINECS999-999-2
- номер MDLMFCD00274570
- файл Mol30562-34-6.mol
химическое свойство
Температура плавления | 255 °C |
Температура кипения | 627.87°C (rough estimate) |
плотность | 1.2443 (rough estimate) |
показатель преломления | 1.5800 (estimate) |
Fp | 87℃ |
температура хранения | -20°C |
растворимость | DMSO: soluble |
форма | powder |
пка | 8.42±0.70(Predicted) |
цвет | yellow to orange |
λмакс | 305nm(MeOH)(lit.) |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
Справочник по базе данных CAS | 30562-34-6(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | Z3K3VJ16KU |
Коды опасности | T,Xi | |||||||||
Заявления о рисках | 36/37/38 | |||||||||
Заявления о безопасности | 26-27-36/37/39-24/25 | |||||||||
WGK Германия | 2 | |||||||||
RTECS | LX8920000 | |||||||||
кода HS | 29419090 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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оператор предупредительных мер
P403+P235:Хранить в прохладном, хорошо вентилируемом месте.
Гелданамицин химические свойства, назначение, производство
Описание
Geldanamycin from Streptomyces hygroscopicus.Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.
Химические свойства
Yellow to Orange PowderИспользование
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.Определение
ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.Общее описание
Chemical structure: benzenoidБиологическая активность
Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.Гелданамицин запасные части и сырье
запасной предмет
Гелданамицин поставщик
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