БРОМОДИФТОРАЦЕТАТ КАЛИЯ

Использование

Potassium bromodifluoroacetate, which can be obtained from readily available ethyl ester, can be a practical alternative to Me3SiCF2Br in reaction with organozincs. Potassium bromodifluoroacetate could be used to synthesise gem-difluorinated compounds from organozinc reagents. Potassium bromodifluoroacetate serves as a source of CF2-fragment, which is inserted into the carbon single bondzinc bond of organozinc reagents. The intermediate difluorinated organozinc species can be protonated, brominated or coupled with allylic electrophiles[1].