![ChemicalBook](https://m.chemicalbook.com/Scripts/New/img/logo.png)
![Фумагиллин структурированное изображение](/CAS/GIF/23110-15-8.gif)
Фумагиллин
- английское имяFumagillin
- CAS №23110-15-8
- CBNumberCB3142925
- ФормулаC26H34O7
- мольный вес458.54
- EINECS245-433-8
- номер MDLMFCD03990453
- файл Mol23110-15-8.mol
химическое свойство
Температура плавления | 194-195℃ |
альфа | D25 -26.6° (c = 1 in 95% ethanol) |
Температура кипения | 484.03°C (rough estimate) |
плотность | 1.1368 (rough estimate) |
показатель преломления | 1.5800 (estimate) |
Fp | 2℃ |
температура хранения | 2-8°C |
растворимость | ethanol: 1 mg/mL |
форма | powder |
пка | 4.27±0.10(Predicted) |
цвет | white |
Чувствительный | Air Sensitive |
Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
ИнЧИКей | NGGMYCMLYOUNGM-ZILXAVPASA-N |
LogP | 3.260 (est) |
FDA UNII | 7OW73204U1 |
Код УВД | P01AX10 |
Коды опасности | Xn,F | |||||||||
Заявления о рисках | 22-36-20/21/22-11 | |||||||||
Заявления о безопасности | 36-36/37-16-24/25 | |||||||||
РИДАДР | UN 1648 3 / PGII | |||||||||
WGK Германия | 3 | |||||||||
RTECS | HE1750000 | |||||||||
кода HS | 29419090 | |||||||||
Токсичность | LD50 in mice (mg/kg): ~800 s.c. (DiPaolo) | |||||||||
NFPA 704: |
|
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
предупреждение
-
вредная бумага
H302:Вредно при проглатывании.
-
оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Фумагиллин химические свойства, назначение, производство
Описание
Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2; IC50 = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells when used at a concentration of 5 μg/ml. In vivo, fumagillin (30 mg/kg per day) decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. It also reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity. Formulations containing fumagillin have been used to treat conjunctival and intestinal microsporidial infections in immunocompromised patients.Химические свойства
White powderИспользование
Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-inf ective and antiangiogenic agent.Определение
An antibiotic substance produced by Aspergillus fumigatus.Общее описание
Fumagillin is an antibiotic obtained by the fermentation of certain strains of Aspergillus fumigatus with potent amoebicidal action.Биологическая активность
Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo . Also inhibits tumor growth in mice. Analog available, TNP 470 (N-(2-Chloroacetyl)carbamic acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl -2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester).Методы очистки
Forty grams of a commercial sample containing 42% fumagillin, 45% sucrose, 10% antifoam agent and 3% of other impurities are digested with 150mL of CHCl3. The insoluble sucrose is filtered off and washed with CHCl3. The combined CHCl3 extracts are evaporated almost to dryness at room temperature under reduced pressure. The residue is triturated with 20mL of MeOH, and the fumagillin is filtered off by suction. It is crystallised twice from 500mL of hot MeOH by standing overnight in a refrigerator (yellow needles). (The long-chain fatty ester used as antifoam agent is still present, but is then removed by repeated digestion, on a steam bath, with 100mL of diethyl ether.) For further purification, the fumagillin (10g) is dissolved in 150mL of 0.2M ammonia, and the insoluble residue is filtered off. The ammonia solution (cooled in running cold water) is then brought to pH 4 by careful addition of M HCl with constant shaking in the presence of 150mL of CHCl3. (Fumagillin is acid-labile and must be removed rapidly from the aqueous acid solution.) The CHCl3 extract is washed several times with distilled water, dried (Na2SO4) and evaporated under reduced pressure. The solid residue is washed with 20mL of MeOH. The fumagillin is filtered off by suction, then crystallised from 200mL of hot MeOH. [Tarbell et al. J Am Chem Soc 77 5610 1955.] Alternatively, 10g of fumagillin in 100mL CHCl3 is passed through a silica gel (5g) column to remove tarry material, and the CHCl3 is evaporated to leave an oil which gives fumagillin on crystallisation from amyl acetate. It recrystallises from MeOH (charcoal) or Me2CO/MeOH. The fumagillin is stored in dark bottles in the absence of oxygen and at low temperatures. [Schenk et al. J Am Chem Soc 77 5606 1955, Beilstein 19 III/IV 1012.]Фумагиллин запасные части и сырье
сырьё
Фумагиллин поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия | |
---|---|---|---|---|---|
+86-19164747840 +86-13119157289 |
China | 2972 | 58 | ||
+86 13288715578 +8613288715578 |
China | 12448 | 58 | ||
+86-13131129325 | China | 5867 | 58 | ||
+8619933239880 | China | 853 | 58 | ||
+86-0371-55170693 +86-19937530512 |
China | 21667 | 55 | ||
+undefined-21-51877795 | China | 32836 | 60 | ||
+86-0371-86658258 +8613203830695 |
China | 29888 | 58 | ||
+86-19930503282 | China | 8821 | 58 | ||
+1-631-485-4226 | United States | 19553 | 58 | ||
+8619521488211 | China | 2534 | 58 |