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Фталилсульфатиазол
- английское имяPhthalylsulfathiazole
- CAS №85-73-4
- CBNumberCB2405964
- ФормулаC17H13N3O5S2
- мольный вес403.43
- EINECS201-627-4
- номер MDLMFCD00005318
- файл Mol85-73-4.mol
химическое свойство
Температура плавления | 198-204°C |
Температура кипения | 371.31℃[at 101 325 Pa] |
плотность | 1.4235 (rough estimate) |
давление пара | 0Pa at 25℃ |
показатель преломления | 1.6390 (estimate) |
температура хранения | Keep in dark place,Sealed in dry,Room Temperature |
растворимость | Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent). |
пка | 3.40±0.36(Predicted) |
форма | Solid |
цвет | White to Light Yellow |
Растворимость в воде | 400mg/L at 28℃ |
Мерк | 14,7377 |
БРН | 359901 |
LogP | -2 at 28℃ |
Справочник по базе данных CAS | 85-73-4(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | 6875L5852V |
Код УВД | A07AB02 |
Справочник по химии NIST | Phthalylsulfathiazole(85-73-4) |
Система регистрации веществ EPA | Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4) |
больше
Заявления о безопасности | 24/25 | |||||||||
РИДАДР | 3249 | |||||||||
RTECS | TH8575000 | |||||||||
Класс опасности | 6.1(b) | |||||||||
Группа упаковки | III | |||||||||
кода HS | 29350090 | |||||||||
Токсичность | LD50 i.p. in mice: 920 mg/kg (Mattis) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H412:Вредно для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P273:Избегать попадания в окружающую среду.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Фталилсульфатиазол химические свойства, назначение, производство
Химические свойства
White or yellowish-white, crystalline powder.Использование
Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.Определение
ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.Подготовка
It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
Всемирная организация здравоохранения(ВОЗ)
Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.Фталилсульфатиазол запасные части и сырье
Фталилсульфатиазол поставщик
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