3-Этил-3-oxetanemethanol

Химические свойства

clear colorless liquid

Использование

3-Ethyl-3-oxetanemethanol is used as pharmaceutical intermediate.

прикладной

Poly(3-ethyl-3-oxetanemethanol) could be used as a core to synthesize amphiphilic hyperbranched polyethers (AHPs), which have multiple linear poly-(ethylene glycol) arms. The AHPs owned good dispersion performance for coating pigment particles. Among AHP's products, AHP47 with 0.47 DB had good potential in coating applications. can also be used to synthesize azobenzene-focused hyperbranched poly(3- ethyl-3-oxetanemethanol)[1-2].

Ссылки на синтез

Journal of the American Chemical Society, 79, p. 3455, 1957 DOI: 10.1021/ja01570a038

Синтез

3-Ethyl-3-oxetanemethanol was prepared by a modified procedure described in the literature. A mixture of trimethylopropane (1, 26.8 g, 0.2 mol), diethyl carbonate (23.6 g, 0.2 mol) and potassium hydroxide (0.1 g, 1.8 mmol) in 2 ml absolute ethyl alcohol was refluxed in oil bath at 110?C for 1 h. Then, the mixture was distilled at 110?C for 1 h. Distillation was continued until the temperature of oil bath reached 140?C. After the distillation, the vacuum was supplied for 1 h to remove the excess solvent. On heating above 185?C, the distilled materials were collected in a cold trap under vacuum and obtained >85% of the theoretical yield. 1H-NMR (CDCl3, δ, ppm): 0.80–0.83 (t, 3H, –CH2CH3), 1.61–1.66 (q, 2H, –CH2CH3), 3.62 (s, 2H, –CH2OH), 3.66 (s, 1H, –CH2OH), 4.31–4.32 and 4.38–4.39 (d, 4H, –CH2O).