АЗОКСИСТРОБИН

Описание

Azoxystrobin is a second broad-spectrum strobilurin fungicide (28,29). It forms white solids with a mp = 116 ?C; vp = 1.1 × 10?7 mPa at 25 ?C; logP = 2.5 at 20?C; water solubility = 6 mg/L; and a half-life of 11 to 17 days for aqueous photolysis.

Химические свойства

White to beige crystalline solid or powder.

Использование

Azoxystrobin has a very broad spectrum of activity and is active against fungal pathogens from all four taxonomic groups, the Oomycetes, Ascomycetes, Deuteromycetes and Basidiomycetes. It controls diseases on cereals, rice, vines, apples, peaches, bananas, citrus, curcurbits, potatoes, tomatoes, peanuts, coffee and turf.

Определение

ChEBI: An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by b ocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.

Опасность

Moderately toxic by inhalation.

Сельскохозяйственное использование

Fungicide: Azoxystrobin has been processed as a Reduced Risk pesticide for Turf uses. Azoxystrobin is a systemic, broad-spectrum fungicide that was first introduced in 1998. It inhibits spore germination and is used on grape vines, cereals, potatoes, apples, bananas, citrus, tomatoes and other crops. Largest crop uses in California are on almonds, rice, pistachios, wine grapes, raisins and garlic. Among the diseases it controls are rusts, downey and powdery mildew, rice blast and apple scab. A U.S. EPA restricted Use Pesticide (RUP)

Торговое название

ABOUND®; AMISTAR®; AMISTAR OPTI; AMISTAR PRO; BANKIT®; HERITAGE®; ICIA5504 80WG®; OLYMPUS®; ORTIVA®; PROTEGE®; PROTEGE-ALLEGIANCE WP®;PROTEGE-FL SEED APPLIED FUNGICIDE®; QUADRIS OPTI®; QUILT®; SOYGARD WITH PROTEGE®

Профиль безопасности

Moderately toxic by inhalation.When heated to decomposition it emits toxic vapors ofNOx.

Возможный контакт

A β-methyoxyacrylate, Strobilurin is an agricultural fungicide.

Метаболический путь

Azoxystrobin is a recently developed fungicide with a novel mode of action (see Overview for relevant references). It was first registered in 1996. It has been and is being subjected to the full range of studies to meet current regulatory requirements for toxicology, metabolism and environmental fate. Information on its metabolism and environmental fate was presented as a lecture at the 9th International Congress of Pesticide Chemistry (IUPAC) in 1998 and this will be published in the Proceedings. The information presented below is derived from this source (Joseph, 1998).
Azoxystrobin is a carboxylic acid methyl ester and one of its pathways of metabolism is via hydrolysis to its carboxylic acid. The latter is not biologically active (see Overview) and the favourable selective toxicity of the fungicide is due to this and other metabolic reactions in non-target species. Azoxystrobin is readily degraded in soil and ultimately mineralised and it is metabolised in plants and animals. Metabolism is complex because the molecule possesses several functional groups. Five different pathways have been identified in plants and animals. Biotransformations occurring on the parent molecule include hydrolysis, aromatic hydroxylation, cleavage of both phenoxy linkages, nitrile to amide hydrolysis and fragmentation of the acrylate double bond. Some photo-induced changes also occur, including conversion to the (Z)-isomer.

Метаболизм

Metabolites are also rapidly degraded in soil. Photolysis studies show a DT₅₀ of 11 days. Due to the rapid degradation and low soil mobility, no leaching is found in field studies.

Перевозки

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Несовместимости

Combustible; dust may form explosive with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Утилизация отходов

Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Dispose of contents and container to an approved waste disposal plant. Use a licensed professional waste disposal service to dispose of this material. Ultimate disposal of the chemical, product, and waste containers must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with public health, local, state, and federal health and environmental regulations. Never reuse or recycle used product containers unless the recycling program specifically accepts pesticide containers and you follow the program’s instructions for preparing the empty containers for collection