Стирипентол

Описание

Stiripentol is a third-generation antiepileptic compound. It is a positive allosteric modulator of GABA_A receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α₃ subunits and to a lower extent in those containing β₁ or ε subunits. It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices. Stiripentol (500 μM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5. Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.

Химические свойства

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Использование

Stiripentol is an epilepsy drug, it has been used as co-therapy for treatment of epilepsy.