![ChemicalBook](https://m.chemicalbook.com/Scripts/New/img/logo.png)
![Феноксибензамин структурированное изображение](/CAS/GIF/59-96-1.gif)
Феноксибензамин
- английское имяphenoxybenzamine
- CAS №59-96-1
- CBNumberCB1933947
- ФормулаC18H22ClNO
- мольный вес303.83
- EINECS200-446-8
- номер MDLMFCD00599580
- файл Mol59-96-1.mol
химическое свойство
Температура плавления | 38-40° |
Температура кипения | 381.5±27.0 °C(Predicted) |
плотность | 1.0513 (rough estimate) |
показатель преломления | 1.5600 (estimate) |
пка | 6.58±0.50(Predicted) |
цвет | Crystals from pet ether |
Справочник по базе данных CAS | 59-96-1 |
FDA UNII | 0TTZ664R7Z |
Система регистрации веществ EPA | N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine (59-96-1) |
Банк данных об опасных веществах | 59-96-1(Hazardous Substances Data) |
Токсичность | LD50 oral in rat: 2500mg/kg |
Феноксибензамин химические свойства, назначение, производство
Использование
Antihypertensive.Всемирная организация здравоохранения(ВОЗ)
Phenoxybenzamine, a long-acting alpha-adrenoreceptor antagonist, was introduced in 1953 and has been used in a variety of peripheral vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it was found to be carcinogenic in the rat. Its approved use was subsequently restricted by several regulatory authorities and phenoxybenzamine is currently used to manage hypertensive episodes associated with phaeochromocytoma, as an adjunct to the short-term management of urinary retention due to neurogenic bladder, in the short-term treatment of benign prostatic hypertrophy in patients awaiting surgery, and in inoperable benign prostatic hypertrophy.Профиль безопасности
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.Методы очистки
The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]Феноксибензамин запасные части и сырье
Феноксибензамин поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
---|---|---|---|---|
+1-781-999-5354 +1-00000000000 |
United States | 19892 | 58 | |
+86-029-89586680 +86-18192503167 |
China | 8840 | 58 | |
+86-27-87465837 +8618971612321 |
China | 9641 | 58 | |
571-88938639 +8617705817739 |
China | 52861 | 58 | |
+8618058761490 | China | 50000 | 58 | |
010-56205725 | China | 12338 | 58 | |
021-021-33632979 15002134094 |
China | 7846 | 58 | |
027-87465837 19945049750 |
China | 9650 | 58 | |
028-85157043 15882256948 |
China | 4395 | 58 | |
13163333255 | China | 395 | 58 |