PERHEXILINE MALEATE SALT
- русский язык имя
- английское имяPERHEXILINE MALEATE SALT
- CAS №6724-53-4
- CBNumberCB1464993
- ФормулаC23H39NO4
- мольный вес393.56
- EINECS229-775-5
- номер MDLMFCD00057329
- файл Mol6724-53-4.mol
химическое свойство
Температура плавления | 181-183°C |
температура хранения | 2-8°C |
растворимость | DMSO: ≥5mg/mL |
форма | powder |
цвет | white to tan |
FDA UNII | K7V8Y90G0H |
WGK Германия | 2 |
RTECS | TM7068000 |
Токсичность | LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri) |
PERHEXILINE MALEATE SALT химические свойства, назначение, производство
Описание
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 μM, respectively) and rat heart CPT2 (IC50 = 79 μM). Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 μM and induces autophagy ~7-fold at a concentration of 10 μM in MCF-7 cells.Химические свойства
White SolidИспользование
PERHEXILINE MALEATE SALT is a Vasodilator, used in treatments for angina.Общее описание
Perhexiline maleate regulates?coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with?papilledema?and proximal myopathy.Профиль безопасности
Poison by intraperitoneal route. Moderately toxic by ingestion.Human systemic effects by ingestion: muscle weakness, paresthesia, and hepatitis. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.PERHEXILINE MALEATE SALT запасные части и сырье
PERHEXILINE MALEATE SALT поставщик
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