HOE 140
- русский язык имя
- английское имяHOE 140
- CAS №130308-48-4
- CBNumberCB1318492
- ФормулаC59H89N19O13S
- мольный вес1304.52
- номер MDLMFCD00213940
- файл Mol130308-48-4.mol
химическое свойство
| плотность | 1.60±0.1 g/cm3(Predicted) |
| температура хранения | Sealed in dry,2-8°C |
| растворимость | Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM) |
| форма | powder |
| пка | 3.60±0.21(Predicted) |
| цвет | white |
| Растворимость в воде | Soluble to 1 mg/ml in water |
| Последовательность | H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH |
| ИнЧИКей | QASONHYHOCRAHL-DOMVFXHKSA-N |
| Справочник по базе данных CAS | 130308-48-4 |
| FDA UNII | 7PG89G35Q7 |
| Код УВД | B06AC02 |
HOE 140 химические свойства, назначение, производство
Описание
Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].Использование
Antagonist (bradykinin).Определение
ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.Имя бренда
Metastat (CollaGenex).Биологическая активность
Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20 nmol kg?1, inhibition still amounted to 60%, whereas the effect of 200 nmol kg?1 of d-Arg—[Hyp2, Thi5,8, d-Phe7]BK was not significant. In receptor binding studies in guinea-pig ileum preparations, Hoe 140 showed an IC50 of 1.07 × 10?9mol l?1 and a KI value of 7.98 × 10?10 mol l?1.HOE 140 поставщик
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