RG108
- русский язык имя
- английское имяRG108
- CAS №48208-26-0
- CBNumberCB0972112
- ФормулаC19H14N2O4
- мольный вес334.33
- номер MDLMFCD08705332
- файл Mol48208-26-0.mol
химическое свойство
| Температура плавления | 192-194℃ |
| Температура кипения | 606.0±50.0 °C(Predicted) |
| плотность | 1.502±0.06 g/cm3(Predicted) |
| температура хранения | -20°C |
| растворимость | DMSO: >10mg/mL |
| пка | 3.62±0.10(Predicted) |
| форма | powder |
| цвет | yellow |
| Чувствительный | Light Sensitive |
| Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Справочник по базе данных CAS | 48208-26-0 |
RG108 химические свойства, назначение, производство
Использование
RG108 has been used:- in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)
- as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells
- as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)
Общее описание
RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.Биологическая активность
Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.RG108 поставщик
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