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SCIADOPITYSIN
- русский язык имя
- английское имяSCIADOPITYSIN
- CAS №521-34-6
- CBNumberCB0273404
- ФормулаC33H24O10
- мольный вес580.54
- EINECS208-311-5
- номер MDLMFCD00017448
- файл Mol521-34-6.mol
химическое свойство
Температура плавления | 296-298°C |
Температура кипения | 839.6±65.0 °C(Predicted) |
плотность | 1.445±0.06 g/cm3(Predicted) |
температура хранения | 2-8°C |
растворимость | Soluble in ethanol and methan |
форма | powder |
пка | 6.16±0.40(Predicted) |
цвет | Light yellow |
LogP | 5.500 (est) |
Справочник по базе данных CAS | 521-34-6 |
FDA UNII | WL44VY201L |
Заявления о безопасности | 24/25 |
кода HS | 29329990 |
SCIADOPITYSIN химические свойства, назначение, производство
Описание
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.Определение
ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.SCIADOPITYSIN поставщик
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