What is the drug carbasalate calcium used for?

Carbasalate calcium also known as ASCAL,  is a drug that merges the therapeutic properties of aspirin and calcium acetylsalicylate, predominantly marketed under various trade names such as Ascal and Demigran. It is the current country The oral analgesic-antipyretic for livestock and poultry of Ministry of Agriculture's approval is uniquely obtained, belongs to national three classes novel chiral synthon.

Clinical Uses

The drug falls under the category of non-steroidal anti-inflammatory drugs (NSAIDs) and is primarily utilized for its analgesic, anti-inflammatory, and antipyretic properties. The compound is specially designed to reduce gastrointestinal irritation, a common side effect associated with regular aspirin use. Carbasalate calcium targets the enzyme cyclooxygenase (COX), which is integral in the formation of pro-inflammatory compounds. The drug is studied extensively across various research institutions globally, showing promising results in treating conditions like rheumatoid arthritis, cardiovascular diseases, and migraines. Research has progressed significantly, with numerous clinical trials backing its efficacy and safety profile.

Mechanism of Action

The mechanism of action of carbasalate calcium revolves around its ability to inhibit the COX enzymes. There are two main types of COX enzymes: COX-1 and COX-2. COX-1 is involved in maintaining the normal lining of the stomach, intestinal tract, and other organs, while COX-2 is primarily involved in inflammation and pain.

After animal is oral, carbasalate calcium can absorb rapidly, and degradation in vivo is salicylic acid, suppress cyclo-oxygenase and peanut Tetraenoic acid synthesis of prostaglandins, so that play antipyretic-antalgic and antiinflammatory action.The Oral drug absorption is rapid, complete, in stomach Have begun to absorb, in the absorbable major part of upper part of small intestine, oral rear blood drug concentration peak time is 15 min～20 min.Carbaspirin is distributed in each tissue after absorbing, the salicylate protein binding rate after hydrolysis is 65%～90%, gives birth to relatively Thing availability is 111.8%. This mechanism makes carbasalate calcium an attractive alternative to traditional NSAIDs, particularly for patients who are prone to gastrointestinal issues.

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