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The applications of Fosfomycin tromethamine

Aug 28，2019

Fosfomycin trometamol (fosfomycin tromethamine) is approved in numerous countries worldwide, mainly for the treatment of uncomplicated urinary tract infections (UTIs). Fosfomycin has good in vitro activity against common uropathogens, such as Escherichia coli (including extended-spectrum β-lactamase-producing E. coli), Proteus mirabilis, Klebsiella pneumoniae and Staphylococcus saprophyticus, and the susceptibility of uropathogens to fosfomycin has remained relatively stable over time.

Article illustration

Applications

Treatment of uncomplicated UTIs (acute cystitis) in women caused by susceptible Escherichia coli or Enterococcus faecalis (formerly Streptococcus faecalis).
Oral fosfomycin (single 3-g dose) is one of several preferred anti-infectives for empiric treatment of uncomplicated cystitis in women.Considered a good choice for such infections since incidence of fosfomycin resistance among uropathogens (e.g., E. coli) is low to date and the single-dose regimen is well tolerated and has not been associated with selection of drug-resistant bacteria or colonization/infection with multidrug-resistant strains.

Dosage and Administration

Has been administered IV†as disodium salt;parenteral formulation not available in US.

Oral Administration

Granules for oral solution must be dissolved in water prior to administration;do not ingest as dry granules.
Prepare oral solution by adding entire contents of single-dose packet (sachet) containing 3 g of the drug to 90–120 mL (3–4 ounces) of water;1 do not use hot water.After stirring to dissolve granules, immediately ingest entire oral solution.

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