Simvastatin: uses and side effects
Introduction
Simvastatin is a prescription drug. It comes in two forms: a tablet and a suspension; both are taken by mouth. Simvastatin oral tablet is available as the brand-name drug Zocor. It's also available as a generic drug. It was patented by Merck in 1980 and came into medical use in 1992. Simvastatin is available as a generic medication and is on the World Health Organization's List of Essential Medicines. In 2022, it was the nineteenth most commonly prescribed medication in the United States, with more than 26 million prescriptions.
Simvastatin, the more potent semisynthetic version of modified lovastatin, became more useful than lovastatin itself. Chemically speaking, simvastatin is butanoic acid, 2,2-dimethyl, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-[(2R,4R)- tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester. It has been obtained via chemical synthesis from lovastatin
History
Simvastatin was the second statin used clinically. Simvastatin, which differs from lovastatin in an additional side chain methyl group, was approved for marketing in Sweden in 1988 and then worldwide. Pravastatin followed in 1991, fluvastatin in 1994, atorvastatin in 1997, cerivastatin in 1998, and rosuvastatin in 2003. Lovastatin is a fermentation product. Simvastatin is a semisynthetic derivative of lovastatin, and pravastatin is derived from the natural product compactin by biotransformation. All other HMG-CoA reductase inhibitors are synthetic products. The mean reduction in LDL cholesterol attainable with the maximal recommended dose of different statins ranges from 35 to 55%.
Uses
It belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." This drug is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).
Statins work to reduce the body's cholesterol production. They also reduce the amount of cholesterol and triglycerides moving through the body. High cholesterol and triglycerides are associated with increased risk of:
heart disease
stroke
heart attack
Statins are usually used in combination with lifestyle changes, such as changes to diet and exercise.
Side effects
Simvastatin oral tablet doesn't cause drowsiness but can cause other side effects.
The more common side effects that can occur with simvastatin include:
headache
nausea
stomach pain
constipation
muscle pain or weakness
joint pain
upper respiratory infections
Serious side effects: Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:
rhabdomyolysis (muscle breakdown)
severe muscle pain or weakness
muscle pain or weakness that does not go away when this drug is stopped
muscle spasms
kidney failure
liver toxicity
jaundice (yellowing of the skin)
severe anemia
severe allergic reaction, with symptoms such as fever and trouble breathing
rash of any kind
extreme sensitivity to the sun
diarrhea
feeling weak or very tired
severe stomach pain
severe nausea or vomiting
severe swelling of the hands, feet, and ankles
);Lastest Price from Simvastatin manufacturers
![79902-63-9 Simvastatin](/ProductImageEN/2021-06/Small/3c2b1d72-9eed-45f5-8ff0-a84c8f480100.jpg)
US $0.00-0.00/Kg/Drum2024-09-02
- CAS:
- 79902-63-9
- Min. Order:
- 1KG
- Purity:
- 98%-101%;USP
- Supply Ability:
- 500 KG
![79902-63-9 Simvastatin](/ProductImageEN/2024-01/Small/d3e892c8-9ce6-496f-a846-b532d9f106bd.jpg)
US $0.00-0.00/kg2024-05-09
- CAS:
- 79902-63-9
- Min. Order:
- 1kg
- Purity:
- 99%, Single impurity<0.1
- Supply Ability:
- 1 ton