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Side effects of loratadine

Dec 15，2022

Loratadine is a tricyclic antihistamine with high efficiency and long-lasting effect. It is a selective peripheral H1 receptor antagonist and can relieve various symptoms caused by allergic reactions.

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Uses of loratadine

Loratadine is mainly used to relieve symptoms related to allergic rhinitis, such as sneezing, runny nose, nasal itching, nasal congestion, and eye itching and burning.

It can be used to relieve the symptoms and signs of chronic urticaria, pruritic skin diseases and other allergic skin diseases.

Loratadine can also be used as an auxiliary drug for allergic asthma, and for anti-allergic treatments such as jellyfish stings and bee stings.

Side effects of loratadine

Common adverse reactions include fatigue, headache, drowsiness, dry mouth, gastrointestinal discomfort (including nausea, gastritis) and rash. Occasionally lethargy, forgetfulness, and facial acral edema in the morning.

Rare adverse reactions include blurred vision, decreased or increased blood pressure, syncope, seizures, breast enlargement, alopecia, allergic reactions, abnormal liver function, tachycardia, palpitations, hyperkinesia, jaundice, hepatitis, hepatic necrosis, polymorphic Sexual erythema, etc.

Occasional mammary gland hyperplasia, erythema multiforme, peripheral edema, epilepsy.

If any discomfort occurs during the medication, please consult your doctor in time.

Interactions of loratadine

1. Taking ketoconazole, cimetidine, theophylline and other drugs at the same time will increase the plasma concentration of loratadine, so it should be used with caution.

2. Loratadine is metabolized by liver CYP450 enzymes, so drugs that inhibit liver drug enzyme activity, such as macrolide antibiotics, can slow down the metabolism of the drug, increase the blood concentration of the drug, and may cause adverse reactions Increase.

3. Combination with other CNS depressants (such as barbiturates, benzodiazepine sedatives, phenothiazine sedatives) and tricyclic antidepressants can cause severe drowsiness.

4. Monoamine oxidase inhibitors can increase the adverse reactions of this product.

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