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Dimethyl Malonate: Protective Potential of Acute Kidney Injury and Toxic Summary

Oct 22，2024

Dimethyl malonate is a chemical compound used extensively in the field of organic synthesis. It acts as a reagent for the malonic ester synthesis, enabling the formation of carboxylic acids with highly controlled carbon-chain lengths.

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Uses

Dimethyl malonate is utilized in carbon-carbon bond formation reactions such as the Knoevenagel condensation, contributing to the synthesis of various alkenes.

Protective Potential of Acute Kidney Injury

Dimethyl malonate has garnered attention as a potential therapeutic agent for acute kidney injury (AKI).

Toxicity

LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg.

Hazards

May cause respiratory irritation. Shall not be classified as a specific target organ toxicant (repeated exposure). Shall not be classified as presenting an aspiration hazard.

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