Application and Research of Benzylamine

Application of Benzylamine

Benzylamine is an aliphatic amine compound with a strong base. It is produced by the reaction between benzyl chloride and ammonia solution. It has a wide range of uses in the pharmaceutical, chemical, paint, textile and other industries. It is an important intermediate in organic synthesis or pharmaceutical products, and can be used to produce active pharmaceutical ingredients and crop protection agents. It is used as a basic component of additives and solvents in the paint industry. It is also a raw material for the production of biotin (vitamin H) and as an intermediate in certain photographic materials.

Research-of-Benzylamine

Promoting CO2 absorption in aqueous amines with benzylamine

Post-combustion capture of CO2 is the most mature technique for reducing greenhouse gas emissions from coal fired power stations. In this study, aqueous benzylamine (BA) was investigated as a potential solvent for CO2 capture. First, CO2 loading capacities in 30% wt/wt aqueous benzylamine were determined by vapour liquid equilibrium (VLE) experiment in a stirred vessel between 40 °C and 80 °C, over a pressure range up to 900 kPa. At 15 kPa and 40 °C, 0.45 mol CO2/mol BA was absorbed. Protonation and carbamate thermodynamic equilibrium constants as well as the standard enthalpy of protonation were determined. Benzylamine showed a similar pKa (8.89 at 40 °C) but a larger pKa variation with temperature than MEA. The carbamate stability constant changed little with temperature. Benzylamine was then investigated as a CO2 absorption rate promoter in aqueous MDEA in a stirred vessel with a plane horizontal gas-liquid interface. Benzylamine performed better than MEA and DEA as a rate promoting agent, a larger amount of benzylamine in aqueous MDEA resulting in a higher enhancement of CO2 absorption rate.

The reduction of food intake induced in mice by benzylamine and its derivatives

Characterisation of the pharmacological profile of non-physiological amine oxidase substrates could help to identify the endogenous role of this class of enzymes. Previous studies have suggested that benzylamine, a common non-physiological substrate for monoamine and tissue-bound or soluble benzylamine oxidases, could behave as a potassium channel blocking agent. Potassium channel blockers are known to modify several forms of animal behaviour including food consumption. To characterise further the pharmacological profile of benzylamine and the role of amine oxidases, we have studied the effect of benzylamine on mice food intake. Our results confirm that benzylamine produces a reduction in mice feeding in a similar manner to that obtained by amphetamine. The anorectic effect of benzylamine and amphetamine in mice was potentiated by pretreatment with amine oxidase inhibitors. In addition, the introduction of substituents in the aromatic ring of benzylamine did not produce compounds with a higher anorectic potency than the one measured with benzylamine.

Liquid-Phase Deamination of Benzylamine and m-Xylylenediamine in the Presence of Nickel Catalysts

The Kinetics of liquid-phase deamination of benzylamine and m-xylylenediaminein the presence of nickel catalysts was studied under the flow of nitrogen at 15°C.The results obtained by using benzylamine agreed well with the rate equationbased upon the Langmuir-Hinshelwood mechanism, the ratio of adsorption equilibrium constant for benzylidene benzylamine to that for benzylamine being 9.3. Itwas suggested that the reaction involved two parallel routes : (1) dehydrogenation of benzylamine, and (2) hydrogen transfer reaction between benzylamine and benzylidene benzylamine. At low conversion of benzylamine, benzylidene benzylaminewas predominantly formed by the former route and at high conversion, benzylidenebenzylamine and dibenzylamine were formed by the latter route. The reactivity of m-xylylenediamine was almost comparable to that of benzylamine. It seemed that the condensate of m-xylylendiamine consisted of its trimer and high polymers.

Refernces:

[1] RICHNER G. Promoting CO2 absorption in aqueous amines with benzylamine[J]. Energy Procedia, 2013. DOI:10.1016/j.egypro.2013.05.127.

[2] L RAIMONDI. The reduction of food intake induced in mice by benzylamine and its derivatives.[J]. Inflammopharmacology, 2003. DOI:10.1163/156856003765764362.

[3] MINORU TASIRO  Masatomo I  S Mituno. Liquid-Phase Deamination of Benzylamine and m-Xylylenediamine in the Presence of Nickel Catalysts.[J]. Journal of Synthetic Organic Chemistry Japan, 1967. DOI:10.5059/YUKIGOSEIKYOKAISHI.25.405.

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