1,4-Butane sultone:Preparation,Toxicity
1,4-butanesultone is a viscous, clear, colorless and odorless liquid
which reacts in boiling water and
alcohols (to 4-alkoxybutanesulfonic acid) and dissolves in many organic
solvents. At temperatures below the melting point, the compound
crystallizes giving "large, magnificent plates".
Preparation
A lab scale synthesis of 1,4-butanesultone starts from 4,4'-dichlorodibutyl ether (accessible from tetrahydrofuran treated with phosphorus oxychloride and concentrated sulfuric acid),which reacts with sodium sulfite forming the corresponding 4,4'-butanedisulfonic disodium salt.
By passing it through an acidic ion exchanger, the disodium salt is converted into the disulphonic acid which forms two molecules of 1,4-butanesultone at elevated temperature and reduced pressure under elimination of water. The yields obtained range from 72 to 80%.
Toxicity
Compared to the homologous γ-sultone 1,3-propanesultone, 1,4-butanesultone is significantly less reactive as alkylating agent, but classified as mutagenic and carcinogenic.
Storage
Store at room temperature
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Lastest Price from 1,4-Butane sultone manufacturers
US $99.00-66.00/kg2025-02-01
- CAS:
- 1633-83-6
- Min. Order:
- 0.0010000000474974513kg
- Purity:
- 99%
- Supply Ability:
- 5000
US $85.00-35.00/kg2025-01-24
- CAS:
- 1633-83-6
- Min. Order:
- 1kg
- Purity:
- 99%
- Supply Ability:
- 20ton