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  • ONO-AE3-208

ONO-AE3-208

ONO-AE3-208
476 1mg 起订
上海 更新日期:2024-03-16

上海宏叶生物科技有限公司

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英文名称:
ONO-AE3-208
CAS号:
402473-54-5
保存条件:
Store at -20°C
纯度规格:
>98%
产品类别:
化合物

ONO-AE3-208 is an inhibitor of EP4 [1].

EP4 is one of the prostaglandin E2 receptors and is associated with inflammatory disease and cancer such as prostate cancer. As an antagonist of EP4, ONO-AE3-208 is expected to be a potential therapy for prostate cancer. In vitro assays show that ONO-AE3-208 can suppress the migration and invasion of prostate cancer cells. 10μM of ONO-AE3-208 decreases wound healing proportion of PC3 and LNCaP cell lines in wound-healing assay. And in Transwell Invasion assay, ONO-AE3-208 inhibits cell invasion even at concentration of 0.1μM. ONO-AE3-208 is also reported to suppress bone metastasis in vivo [1].

Since activation of E2 can increase the expression of matrix metalloproteinase (MMP) and release inflammatory cytokines, and then exacerbates abdominal aortic aneurism (AAA) formation, ONO-AE3-208 is also used in the studies of AAA formation. It has been proved that ONO-AE3-208 can cause the elastic fiber degradation and inhibit AAA formation in vivo in a dose-dependent manner [2].

References:
[1] Song Xu, Zhengyu Zhang, Osamu Ogawa,Takeshi Yoshikawa, Hiromasa Sakamoto, Noboru Shibasaki, akayuki Goto, Liming Wang, Naoki Terada. An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration and metastasis of prostate cancer. Cell Biochem Biophys. 2014, April.
[2] Utako Yokoyama, Ryo Ishiwata, Mei-Hua Jin, Yuko Kato, Orie Suzuki, Huiling Jin, Yasuhiro Ichikawa, Syun Kumagaya, Yuzo Katayama, Takayuki Fujita, Satoshi Okumura, Motohiko Sato, Yukihiko Sugimoto, Hiroki Aoki, Shinichi Suzuki, Munetaka Masuda, Susumu Minamisawa, Yoshihiro Ishikawa. Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation. Plos One. 2012, May. 7, 5, e36724.

GC15662;AE 3-208;ONO AE3 208; EP4;affinity and selecti;

公司简介

上海宏叶生物科技有限公司是一家集研发、销售与技术服务为一体的高新技术企业。公司专业经营生命科学领域的化学试剂,多肽,抑制剂和抗体,并提供生命科学前沿研究技术服务,致力于打造一个专业的一站式购物和服务平台,其产品包括微生物学、分子生物学、细胞生物 学、免疫学、蛋白研究、信号传导和神经科学等领域。

成立日期 (7年)
注册资本 500万
员工人数 10-50人
年营业额 ¥ 300万-500万
经营模式 贸易,试剂,定制,服务
主营行业 中间体,化学试剂,医药中间体,手性化学试剂,有机合成试剂

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