AZD-0364

AZD0364 is an ERK1 and/or ERK2 kinase for the treatment of cancer. ERK1 and ERK2 kinases are ubiquitously expressed MAPK kinases that participate in the RAS-RAF-MEK-ERK signalling cascade in the regulation of cell cycle progression, cell proliferation, survival, metab. and transcription. The RAS-RAF-MEK-ERK signalling cascade is deregulated in a variety of diseases including brain injury, cancer, cardiac hypertrophy, diabetes, and inflammation. In particular the RAS-RAF-MEK-ERK signalling cascade is an attractive pathway for anti-cancer therapies across a broad range of human tumors.