Recombinant Human AITR Ligand/TNFSF18 (Recombinant Human Activation-induced TNFR member Ligand/TNFSF18; rHuAITR Ligand/TNFSF18);重组人诱导激活TNFR成员配体/TNFSF18
Synonyms
TNFSF18; Activation-inducible TNF-related ligand; AITRLMGC138237; GITRLglucocorticoid-induced TNFR-related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRLGITR ligand; TL6AITR ligand; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand superfamily member 18
Purity
>98% by SDS-PAGE and HPLC analyses.
Biological Activity
Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10ng/ml.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.
Endotoxin
Less than 0.1EU/μg of rHuAITR Ligand/TNFSF18 as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
Category
Cytokine
Background
TNFSF18, also named as AITRL, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family and it is encoded by the TNFSF18 gene. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. It is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. Recombinant human TNFSF18 is a 14.3kDa protein, containing 126 amino acid residues and it shares 56% and 60%a.a. sequence identity with murine and rat TNFSF18, respectively.