Thiazovivin

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抑制剂描述：

产品名称：Thiazovivin

产品别名：N-苄基-2-(嘧啶-4-基氨基)噻唑-4-羧酰胺

英文别名：Tzv

靶点：ROCK

CAS：1226056-71-8

纯度：>98%

外观：white to beige to brown Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells

溶解性：DMSO : ≥ 30 mg/mL (96.35 mM)

体外研究：

Thiazovivin is a ROCK inhibitor. Thiazovivin (2 μM) inhibits ROCK activity and protects human embryonic stem cells (hESCs). Thiazovivin significantly increases the survival of hESCs after dissociation while maintaining pluripotency. Thiazovivin enhances cell-ECM adhesion-mediated integrin signaling. Thiazovivin also stabilizes E-cadherin after cell dissociation to protect hESCs from death under ECM-free conditions. Thiazovivin increases cellular attachment of embryo-derived stem-like cells (eSLCs) of cattle and formation of primary colonies on the feeder layer. Thiazovivin reinforces putative colony outgrowth and supports the expansion of eSLC cultures during the subculture for passaging. Furthermore, Thiazovivin causes greater expression of ectodermal lineage-specific genes in eSLCs of cattle.

体内研究：

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