Beclin-1 Antibody

询价 0.1mg 起订

其他更新日期：2024-05-14

深圳市豪地华拓生物科技有限公司

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联系人：深圳市豪地华拓生物科技有限公司

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产品详情:

英文名称：: Beclin-1 Antibody

形态：: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

宿主：: Rabbit

克隆性：: 多克隆

浓度：: 见详细说明信息

货号：: 200212

抗体名：: Beclin-1 Antibody

标记物：: 见下方详细说明

保存条件：: Store at -20°C. Product is guaranteed 1 year from the date of shipment.

适应物种：: H, M, R

抗体英文名：: Beclin-1 Antibody

免疫原：: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser15 of human beclin-1.

应用范围：: E, WB

靶点：: Beclin-1

规格：: 0.1 mg

亚型：: Rabbit Ig

Beclin-1 Antibody产品详细介绍：

产品名称：	Beclin-1 Antibody
说明书：	【点击查看详细说明及参考图片】
货号：	200212
规格：	0.1 mg
产品描述：	Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. ULK1 protein kinase and the VPS34 lipid kinase are key regulators of autophagy initiation and progression. Activated during low nutrient conditions, ULK1 directly phosphorylates Beclin-1 at multiple sites including Ser15.
克隆类型：	Rabbit Polyclonal Antibody
亚型：	Rabbit Ig
免疫原：	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser15 of human beclin-1.
适用物种：	H, M, R
应用范围：	E, WB
应用说明：	Cat. No. 200212 recognizes total Beclin-1, i.e. unphosphorylated and phosphorylated at Ser15 (Ser14 in mouse). E: 1:1,000-1:5,000; WB: 1:500-1:2,000
别名：	Beclin-1 ; Coiled-coil myosin-like Bcl-2-interacting protein; Protein GT197; BECN1
形态：	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
保存条件：	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed 1 year from the date of shipment.
参考文献：

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Beclin-1 Antibody;抗体

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