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Beclin-1 Antibody

Beclin-1 Antibody
3150 1EA 起订
上海 更新日期:2020-01-17

上海振誉生物科技有限公司

非会员
联系人:上海振誉生物
手机:15801849740 拨打
邮箱:2836767067@qq.com

产品详情:

英文名称:
Beclin-1 Antibody
保存条件:
低温
保质期:
一年
货号:
Beclin-1 Antibody
英文名:
Beclin-1 Antibody
规格:
100 ul (10 western blots)
CAS号:
WB , IP ,
数量:
大量
供应商:
科敏商城

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品牌:CST,产品名称:Beclin-1 Antibody #3738
英文名称:Beclin-1 Antibody
Product name:Beclin-1 Antibody #3738
Source:Rabbit
Sensitivity:Endogenous
MW(kDa):60
Reactivity:H,M,R
Applications:WB , IP ,
Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding threonine 72 of human Beclin-1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions (1). One of the proteins critical to this process is Beclin-1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30 (2). Beclin-1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells (3). Mammalian Beclin-1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak (4). While Beclin-1 is generally ubiquitously expressed, research studies have shown it is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers (5). Beclin-1 is localized within cytoplasmic structures including the mitochondria, although overexpression of Beclin-1 reveals some nuclear staining and CRM1-dependent nuclear export (6). Investigators have demonstrated that Beclin-1-/- mice die early in embryogenesis and Beclin-1-/+ mice have a high incidence of spontaneous tumors. Stem cells from the null mice demonstrate an altered autophagic response, although responses to apoptosis appeared normal (7). Researchers have also found that overexpression of Beclin-1 in virally infected neurons in vivo resulted in significant protection against Sindbis virus-induced disease and neuronal apoptosis (4).

Entrez-Gene Id

8678

Swiss-Prot Acc.

Q14457

Specificity / Sensitivity:

Beclin-1 Antibody detects endogenous levels of total Beclin-1 protein.

Species Reactivity:

Human, Mouse, Rat

ApplicationDilutions
Western Blotting1:1000
Immunoprecipitation1:100
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

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温馨提示:不可用于临床治疗。
Beclin-1 Antibody;试剂

公司简介


成立日期 (9年)
注册资本 500万人民币
员工人数
年营业额
经营模式
主营行业

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