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Angiotensin 1-7

Angiotensin 1-7
询价 1EA 起订
上海 更新日期:2024-11-05

上海煊翎生物科技有限公司

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产品详情:

英文名称:
Angiotensin 1-7
货号:
HY-12403 (Angiotensin-(1-7);Ang-(1-7))
产品用途:
其它
英文名:
Angiotensin 1-7
规格:
50mg///500ml///1g
CAS号:
51833-78-4
Angiotensin 1-7的生物活性 Angiotensin (1-7) is a endogenous peptide fragment which can induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. IC50 value: Target: in vitro: Treatment with Ang-(1-7) reversed MGA-induced cellular hypertrophy and myofibroblast transition evidenced by reduced immunostaining and protein expression of α-smooth muscle actin (α-SMA) [0.4±0.1 vs. 1.0±0.1, respectively, n=3, p<0.05]. Ang-(1-7) abolished AGE-induced activation of the MAP kinase ERK1/2 to a similar extent as the TGF-β receptor kinase inhibitor SB58059; however, Ang-(1-7) did not attenuate the MGA-stimulated release of TGF-β [1]. Ang-(1-7) increased ABCA1 and ABCG1 expression in a concentration-dependent manner at both the mRNA and protein levels, promoted cholesterol efflux, and decreased cholesterol content in THP-1 macrophages treated with AngII. Moreover, Ang-(1-7) upregulated the expression of LXRα in a concentration-dependent manner in these cells. LXRα small interfering RNA, as well as the Mas receptor antagonist A-779, completely abolished these effects of Ang-(1-7) [2]. Ang (1-7), through a mechanism dependent on Mas, prevents the decrease in the levels of MHC and the increase in the expression of the atrogin-1 and MuRF-1, both induced by AngII. Ang (1-7) induces AKT phosphorylation in myotubes; additionally, we demonstrated that the inhibition of AKT with MK-2206 decreases the anti-atrophic effects of Ang (1-7) [3]. in vivo: Oral feeding of mice with bioencapsulated ACE2/Ang-(1-7) significantly reduced endotoxin-induced uveitis (EIU) in mice. Treatment with bioencapsulated ACE2/Ang-(1-7) also dramatically decreased cellular infiltration, retinal vasculitis, damage and folding in experimental autoimmune uveoretinitis (EAU) [4]. Ang-(1-7) reversed diabetes-induced abnormal reactivity to vasoactive agents (endothelin-1, phenylepherine, and carbachol) in the CC without correcting hyperglycemia. Six weeks of diabetes led to elevated ACE, ROCK1, ROCK 2, and omega-hydroxylase and a concomitant decrease in ACE2 protein expression levels that were normalized by Ang-(1-7) treatment but not upon coadministration of A779 [5].
Angiotensin 1-7;原辅料包材

公司简介

上海煊翎生物科技有限公司成立于2011年,公司主要经营进口高品质细胞培养试剂以及常见化学试剂。目前是澳洲AusgeneX品牌细胞培养产品中国经销商,澳洲Bovogen以及德国SeraPure的一级授权代理商。公司立志以优质的产品,诚实的信誉保障,优惠的价格,在细胞培养领域与代理商建立合作/服务工业客户,共同努力,达成共赢!

成立日期 (14年)
注册资本 50.000000万人民币
员工人数 50-100人
年营业额 ¥ 100万-300万
经营模式 贸易,工厂,试剂,定制,服务
主营行业 生化试剂,抗体,蛋白组学,分子生物学,免疫安全

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