化合物Angiotensin 1-7|T7339|TargetMol

Angiotensin (1-7)
51833-78-4

￥243 2mg 起订

￥428 5mg 起订

￥672 10mg 起订

上海更新日期：2024-09-24

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产品详情:

中文名称：: 化合物Angiotensin 1-7

英文名称：: Angiotensin (1-7)

CAS号：: 51833-78-4

品牌：: TargetMol

产地：: 美国

保存条件：: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 100%

产品类别：: 抑制剂

货号：: T7339

Product Introduction

Bioactivity

名称	Angiotensin (1-7)
描述	Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activities.
细胞实验	Cultured cardiomyocytes were treated with PBS (control), ANG II (100 nM), ANG-(1–7) (100 nM), ANG II + ANG-(1–7), ANG II + ANG-(1–7) + A779 (10 μM), ANG II + ANG-(1–7) + Sirt3 short hairpin (sh)RNA, lentiviral particles (1 × 10^6 TU) containing a Sirt3 shRNA viral vector, or ANG II + Mito-TEMPO (0.1 μM) for 24 h. Each treatment was performed in triplicate wells. Monoclonal anti-α-sarcomeric actin antibody was used for identification and measurement of cardiomyocytes via immunofluorescence staining. Cells were fixed in methanol at ?10°C and washed with fresh washing solution (0.1% Triton X-100 in PBS) three times. After preincubation with 3% BSA for 20 min, cells were incubated with primary antibody, which was diluted to 1:100 with PBS containing 3% BSA, overnight at 4°C. After three washings with the washing solution, cells were incubated with fluorescence-conjugated anti-mouse IgG (1:500 diluted in PBS) for 1 h at room temperature. Photographic images of cardiomyocytes were taken with a fluorescence microscope. Image-analysis software was used to measure the cell surface area of cardiomyocytes that were positively stained for sarcomeric actin. Variations in cell size were expressed as relative cell surface area versus the control. At least 50 cells in each dish were randomly selected for surface area analysis[1].
动物实验	Eighteen dogs were randomly assigned to sham group, pacing group and Ang-(1-7) group. Rapid atrial pacing was maintained for 14 days in the pacing and Ang-(1-7) groups. Ang-(1-7) was administered intravenously in the Ang-(1-7) group. The atrial effective refractory period and atrial fibrillation inducibility level were measured at baseline and under sympathetic nerve stimulation after 14 days of measurement. The atrial sympathetic nerves labeled with tyrosine hydroxylase were detected using immunohistochemistry and Western blotting, and tyrosine hydroxylase and nerve growth factor mRNA levels were measured by reverse transcription polymerase chain reaction[2].
体外活性	ANG-(1-7)显著减轻了ANG II引起的大鼠心脏肥大和周血管纤维化。这些ANG-(1-7)的效果在培养的心肌细胞中得到了证实，其中ANG-(1-7)显著减轻了ANG II引导的细胞大小增加[1]。
体内活性	Ang-(1-7)处理减轻了心房有效不应期的缩短和心房颤动诱导能力水平的增加。免疫组化和Western blotting结果显示，起搏组存在交感神经过度增生，而Ang-(1-7)减轻了交感神经的增殖。Ang-(1-7)缓解了起搏引起的酪氨酸羟化酶及神经生长因子mRNA表达水平的增加[2]。
存储条件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 8.99 mg/ml (10 mM)
关键字	Endogenous Metabolite \| Angiotensin Receptor \| Angiotensin (17) \| Ang \| Inhibitor \| Angiotensin (1-7) \| inhibit \| Angiotensin \| Angiotensin (1 7) \| Angiotensin-converting Enzyme (ACE)
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ASP-ARG-VAL-TYR-ILE-HIS-PRO|||Angiotensin 1-7|||Ang-(1-7)|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

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