氢溴酸加兰他敏

Galantamine HBr

Galantamine HBr is a strong (reversible) cholinesterase inhibitor that increases the susceptibility of an organism to acetylcholine, and is an effective treatment for mild to moderate dementia of the Alzheimer's type.

We extract our Galanthamine Hydrobromide from Lycoris radiata (L.Herit.) Herb. Our production facility was inspected and classified as acceptable by the United States Food and Drug Administration in 2006 & 2011. To ensure the stable supply of Galanthamine HBr, a large area of herbs have been cultivated and advanced extract technology has been adopted for both enhancing the yield and purifying fine products.

Biological effects

Galanthamine extract is specific, competitive and reversible acetylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine and nicotine receptors have been suggested as areas related to cognitive impairment. Initially, Galanthamine extract was used in anesthesiology to antagonize the effects of non-depolarizing muscle relaxants, and since then it was rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology, gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.

Galanthamine extract is a product with broad therapeutic index, allowing "soft" manifestation of its effect with individual dosing depending on the particular case.

Several trials already showed that Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo and proved also to be very effective in symptomatic treatment of senile dementia of Alzheimer's type