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网站主页 化工产品目录 生物化工 抑制剂 酪氨酸蛋白激酶/信号转导子和转录活化子抑制剂(JAK/STAT) JAK 抑制剂 N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺 TG101209
  • TG101209

TG101209

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide
上海 更新日期:2022-07-26

上海化成医药化工有限公司

非会员
联系人:Mr Shi
电话:13621923966拨打
手机:13621923966 拨打
邮箱:657413374@qq.com

产品详情:

中文名称:
TG101209
英文名称:
N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide
CAS号:
936091-14-4

TG101209 is a potent and small molecule JAK2-selective kinase inhibitor with IC50 of 6, 25, 17 and 169 nM for JAK2, FLT3, RET and JAK3, respectively.TG101209 potently prevents myeloproliferative disorder-related JAK2V617F and MPLW515L/K mutations. Besides, TG101209 suppressed the activation of STAT3 and survivin expression and sensitized HCC2429 and H460 cells to radiation in clonogenic assays. Immunohistochemistry staining of tumor sections showed that TG101209 enhanced apoptosis and decreased cell proliferation and vascular density, suggesting that TG101209 also has antiangiogenic effects.

TG101209

公司简介

Shanghai H&C Chemical Co.,Ltd. is a innovative company engaged in organic intermediates, pharmaceutical ingredients, fine chemicals and custom synthesis. H&C have high experience from lab to semiwork and commercial production,and manufacturing team have high experience in cost saving, process improvement and quality control. H&C are high appraised by our customers for excellent quality and good price.

成立日期
注册资本
员工人数 10-50人
年营业额 ¥ 1000万-5000万
经营模式 工厂,定制,服务
主营行业 医药中间体,合成材料中间体,原料药,有机合成药,液晶中间体

TG101209相关厂家报价

  • 936091-14-4
  • 936091-14-4
  • 成都彼样生物科技有限公司 VIP
  • 2024-12-19
  • 询价
  • TG101209
  • TG101209
  • 南京百鑫德诺生物科技有限公司
  • 2024-09-26
  • ¥700
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