6-溴-2-甲氧基-3-甲基喹啉

JANSSEN PHARMACEUTICA N.V., WO2005/54210, A1, (2005) Example A3 a) Preparation of intermediate 5 A mixture of 6-bromo-2-chloro-3-methyl-quinoline (0.044 83 mol) and CH3ONa (0.224 mol) in MeOH (200ml) was stirred at 70°C for 36 hours. The mixture was coo led, poured into ice, EtOAc was added and the mixture was extracted with EtOAc. The organic layer was washed with water, dried (MgSO4), filtered off and evaporated, yielding llg (97percent) of interme diate 5