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  • Ivacaftor (VX-770)

Ivacaftor (VX-770)

Ivacaftor (VX-770)
北京 更新日期:2012-05-28

Selleckchem LLC

非会员
联系人:Marketing
电话:+1-832-582-8158拨打
邮箱:marketing@selleckchemicals.com

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中文名称:
Ivacaftor (VX-770)
英文名称:
Ivacaftor (VX-770)
CAS号:
873054-44-5

Ivacaftor (VX-770) also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore,Ivacaftor (VX-770) reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures.

CFTR Inhibitors;VX-770

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