产品编号 |
产品名称 |
产品包装 |
产品价格 |
P7257-20μg |
Recombinant Human Bcl-2 |
20μg |
1152.00元 |
Species
|
Gene ID
|
Accession
|
Source
|
Length
|
MW
|
Tag
|
Human
|
596
|
P10415
|
E. coli
|
210aa
|
23kDa
|
-
|
About this Antibody
|
Name
|
Recombinant Human Bcl-2 (Recombinant Human B-cell Lymphoma 2; rHuBcl-2);重组人B细胞淋巴瘤2
|
Synonyms
|
apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2
|
Purity
|
>95% by SDS-PAGE and HPLC analyses.
|
Biological Activity
|
Test in Process.
|
Physical Appearance
|
Sterile liquid.
|
Formulation
|
0.2μm filtered concentrated solution in 25mM Tris-HCl, pH8.0, 100mM NaCl, 1mM DTT, 30% Glycerol, with Tween-80.
|
Endotoxin
|
Less than 0.1EU/μg of rHuBcl-2 as determined by LAL method.
|
Reconstitution
|
N/A
|
Category
|
Others
|
Background
|
B-cell lymphoma 2 (Bcl-2) is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human. Bcl-2 forms homodimer and heterodimers with other Bcl-2 family proteins, like BAX, BAK, BAD and Bcl-xL. Alternative splicing of Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity. Bcl-2 suppresses apoptosis by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In some cases, the presence or absence of Bcl-2 staining in biopsies may be significant for the patient's prognosis or likelihood of cancer relapse. Mature human Bcl-2 shares 88%-90% amino acid sequence identity with murine, rat, bovine, canine Bcl-2.
|
Amino Acid Sequence
|
AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD
|
包装清单:
产品编号
|
产品名称
|
包装
|
P7257-5μg
|
Recombinant Human Bcl-2
|
5μg
|
P7257-20μg
|
Recombinant Human Bcl-2
|
20μg
|
P7257-100μg
|
Recombinant Human Bcl-2
|
100μg
|
P7257-1mg
|
Recombinant Human Bcl-2
|
1mg
|
-
|
说明书
|
1份
|
保存条件:
-20℃或更低温度保存,至少一年有效。由于蛋白的每次冻融均会引起部分失活,所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液),须分装后-20℃或更低温度冻存,以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用,溶液中的蛋白很容易粘附在管壁上,并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein,如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点,使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。