产品编号 |
产品名称 |
产品包装 |
产品价格 |
P5430-20μg |
Recombinant Human TL-1A/TNFSF15 |
20μg |
1152.00元 |
Species
|
Gene ID
|
Accession
|
Source
|
Length
|
MW
|
Tag
|
Human
|
9966
|
O95150
|
E. coli
|
180aa
|
20.5kDa
|
-
|
About this Antibody
|
Name
|
Recombinant Human TL-1A/TNFSF15 (Recombinant Human TNF Ligand-related Molecule 1/TNFSF15; rHuTL-1A/TNFSF15);重组人肿瘤坏死因子配体相关分子1/TNFSF15
|
Synonyms
|
TNFSF15; VEGI; MGC129934; MGC129935; TL1A; TL1Vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; vascular endothelial growth inhibitor-192A; VEGI192A; VEGITNF ligand-related molecule 1
|
Purity
|
>97% by SDS-PAGE and HPLC analyses.
|
Biological Activity
|
Fully biologically active when compared to standard. The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20ng/ml, corresponding to a specific activity of >5.0×104IU/mg.
|
Physical Appearance
|
Sterile Filtered White lyophilized (freeze-dried) powder.
|
Formulation
|
Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4, with 0.02% Tween-20.
|
Endotoxin
|
Less than 0.1EU/μg of rHuTL-1A/TNFSF15 as determined by LAL method.
|
Reconstitution
|
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
|
Category
|
Cytokine
|
Background
|
TL-1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). TL-1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-α and IL-1α. TL-1A binds with high affinity to death receptor 3 (DR3), known as TNFRSF25. Depending on the cell context, ligation of DR3 by TL-1A can trigger one of two signaling pathways, activation of the transcription factor NF-kB, or activation of caspases and apoptosis. Recombinant human TL-1A is a 20.5kDa polypeptide of 180 amino acid residues.
|
Amino Acid Sequence
|
LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VRQTPTQHFK NQFPALHWEH ELGLAFTKNR MNYTNKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL
|
包装清单:
产品编号
|
产品名称
|
包装
|
P5430-5μg
|
Recombinant Human TL-1A/TNFSF15
|
5μg
|
P5430-20μg
|
Recombinant Human TL-1A/TNFSF15
|
20μg
|
P5430-100μg
|
Recombinant Human TL-1A/TNFSF15
|
100μg
|
P5430-1mg
|
Recombinant Human TL-1A/TNFSF15
|
1mg
|
-
|
说明书
|
1份
|
保存条件:
-20℃或更低温度保存,至少一年有效。由于蛋白的每次冻融均会引起部分失活,所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液),须分装后-20℃或更低温度冻存,以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用,溶液中的蛋白很容易粘附在管壁上,并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein,如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点,使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。