Recombinant Murine IL-36 Receptor Antagonist

Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

54450

Q9QYY1

E. coli

154aa

16.9kDa

－

About this Antibody

Name

Recombinant Murine IL-36 Receptor Antagonist (Recombinant Murine Interleukin-36 Receptor Antagonist Protein ; rMuIL-36RA)；Recombinant Mouse IL-36 Receptor Antagonist ; 重组小鼠白细胞介素36受体拮抗剂

Synonyms

FIL1 delta; IL1F5; IL-1HY1; IL-1L1; IL-1RP3; IL36RN; IL36RA; IL-36RA; Interleukin 36 Receptor Antagonist; Interleukin-36 Receptor Antagonist

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 1EU/μg of rMuIL-36RA as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1 family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.IL-36RA has been reported to antagonize the biological activity of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). Furthermore, it could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirect evidence suggests it is IL-1Rrp2. Recombinant murine interleukin-36 RA contains 154 amino acid residues and it shares 91%a.a. sequence identity with human IL-36RA.

Amino Acid Sequence

VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD

产品编号

产品名称

包装

P5993-2μg

Recombinant Murine IL-36 Receptor Antagonist

2μg

P5993-10μg

Recombinant Murine IL-36 Receptor Antagonist

10μg

P5993-100μg

Recombinant Murine IL-36 Receptor Antagonist

100μg

P5993-1mg

Recombinant Murine IL-36 Receptor Antagonist

1mg

-

说明书

1份