Recombinant Rat IL-2

Species

Gene ID

Accession

Source

Length

MW

Tag

Rat

116562

P17108

E. coli

135aa

15.5kDa

－

About this Antibody

Name

Recombinant Rat IL-2 (Recombinant Rat Interleukin-2; rRtIL-2)；重组大鼠白细胞介素2

Synonyms

aldesleukin; Aldesleukin; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.2ng/ml, corresponding to a specific activity of >5.0×10⁶IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

A 0.2μm filtered concentrated sterile solution in 10mM sodium citrate, pH4.0.

Endotoxin

Less than 1EU/μg of rRtIL-2 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4⁺ and CD8⁺ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for Tcell proliferation and other fundamental functions which are essential for the immune response. The receptor for IL-2 consists of three subunits (55kDa IL2Rα, 75kDa IL2Rβ, 64kDa common gamma chain γc/IL2Rγ) that are present on the cell surface in varying preformed complexes. Recombinant rat IL-2 is a 15.3kDa protein containing 134 amino acid residues and it shares about 82%, 66%, 66%, 60% and 54% amino acid sequence identity with mouse, human, rhesus macaque, pig and equus caballus IL-2, respectively.

Amino Acid Sequence

APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ

产品编号

产品名称

包装

P6254-5μg

Recombinant Rat IL-2

5μg

P6254-20μg

Recombinant Rat IL-2

20μg

P6254-100μg

Recombinant Rat IL-2

100μg

P6254-1mg

Recombinant Rat IL-2

1mg

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说明书

1份