SGK1 Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IHC, FC

H, M, R

55.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000

1:10-1:50

-

1:50-1:200

-

1:50-1:100

-

-

About this Antibody

Name

SGK1 Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

6446(Human); 20393(Mouse); 29517(Rat)

SwissProt

O00141(Human); Q9WVC6(Mouse); Q06226(Rat)

Synonyms

SGK

Category

PI3K/Akt/mTOR

Background

Serum- and glucocorticoid-regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1 (also known as protein kinase B or PKB). SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositide-dependent protein kinase 1 (PDK1) capable of phosphorylating the activation-loop of SGK at Threonine-256. The adrenal corticosteroid hormone, Aldosterone, induces the transcription of SGK, which mediates Na + transport by stimulating epithelial sodium channel activity. The SGK promoter contains a glucocorticoid response element and an SP-1 regulatory element, and is a transcriptional target for p53. SGK is also a component of the p38 MAPK-mediated response to hyperosmotic stress. The human SGK gene maps to chromosome 6q23 and encodes the 431-amino acid SGK protein.

产品编号

产品名称

包装

AF1909

SGK1 Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

-

说明书

1份