STAT6 Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IF, IP, IHC, ICC

H, M

94.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000-1:2,000

-

1:50-1:200

1:50-1:200

1:50-1:200

-

-

-

About this Antibody

Name

STAT6 Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

6778(Human); 20852(Mouse)

SwissProt

P42226(Human); P52633(Mouse)

Synonyms

D12S1644; IL-4-STAT; STAT6B; STAT6C

Category

Immunology/Inflamation

Background

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of proteins that have been designated Stats (signal transducers and activators of transcription). The first members of this family to be described include Stat1α p91, Stat1β p84 (a form of p91 that lacks 38 COOH-terminal amino acids) and Stat2 p113. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Stat3, which becomes activated in response to epidermal growth factor (EGF) and interleukin-6 (IL-6), but not interferon-© (IFN-©) or Stat4, is an additional member of this family. It has been suggested that the phosphorylated forms of both Stat3 and Stat4 form homodimers as well as heterodimers with the other members of the Stat family, and that differential activation of different Stat proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Other members of the Stat family include Stat5, which has been shown to be activated by prolactin and by IL-3, and Stat6 (also designated IL-4 Stat), which is involved in IL-4-activated signaling pathways.

产品编号

产品名称

包装

AF1534

STAT6 Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

-

说明书

1份