SUMO-1 Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IF, IHC, ICC, FC, ChIP

H, M, R

12.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000-1:2,000

1:10-1:50

1:50-1:200

1:50-1:200

1:50-1:200

1:50-1:100

-

1:10-1:50

About this Antibody

Name

SUMO-1 Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

7341(Human); 22218(Mouse); 301442(Rat)

SwissProt

P63165(Human); P63166(Mouse); Q5I0H3(Rat)

Synonyms

DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1

Category

Autophagy; Metabolism; Ubiquitin

Background

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.

产品编号

产品名称

包装

AF1453

SUMO-1 Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

-

说明书

1份