Ubiquitin Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IF, IHC, ICC, FC

H, M, R

55.0kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000-1:2,000

-

1:50-1:200

1:200-1:500

1:50-1:200

1:50-1:100

-

-

About this Antibody

Name

Ubiquitin Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

7314/7316/6233/7311(Human); 22187/22190/78294/22186(Mouse); 192255/100912032/64156(Rat)

SwissProt

P0CG47/P0CG48/P62979/P62987(Human); P0CG49/P0CG50/P62983/P62984(Mouse); P0CG51/P62982/P62986(Rat)

Synonyms

FLJ25987; MGC8385; Polyubiquitin B; RPS 27A; UBA 52; UBA 80; UBC; UBCEP 1; UBCEP 2

Category

Ubiquitin

Background

Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. This antibody reacts with ubiquitin, a polypeptide w/ Mr. of approx. 8.5kD. It reacts with physiologically occurring conjugates of ubiquitin and intracellular proteins. Specifically recognizes ubiquitinated cytoplasmic inclusion bodies.

产品编号

产品名称

包装

AF1705

Ubiquitin Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

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说明书

1份