EGFR Rabbit Monoclonal Antibody

来源

用途

交叉反应性

分子量

Rabbit

WB, IP, IF, IHC, ICC, FC

H, M, R

150/50 kDa

WB

IP

IF

IHC

ICC

FC

ELISA

ChIP

1:1,000-1:2,000

1:10-1:50

1:100-1:500

1:50-1:200

1:100-1:500

1:50-1:100

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About this Antibody

Name

EGFR Rabbit Monoclonal Antibody

Category

Rabbit Monoclonal Antibody (RabMAb); Primary antibody

Isotype

IgG

Purification

Affinity purification

About the Immunogen

Immunogen

Recombinant protein

Gene ID

1956(Human); 13649(Mouse)

SwissProt

P00533(Human); Q01279(Mouse); Q9WTS1(Rat)

Synonyms

ERBB; ERBB1; HER1; NISBD2; PIG61; mENA

Category

Protein Tyrosine Kinase

Background

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.

产品编号

产品名称

包装

AF1330

EGFR Rabbit Monoclonal Antibody

50μl

AZ050

Western一抗稀释液

50ml

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说明书

1份