霉酚酸

Mycophenolic acid
24280-93-1

北京更新日期：2012-01-11

北京五洲元业科贸公司

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产品详情:

中文名称：: 霉酚酸

英文名称：: Mycophenolic acid

CAS号：: 24280-93-1

Mycophenolic acid 霉酚酸麦可酚酸

Mycophenolic acid
Mycophenolic acid
M3536 - powder, BioReagent, suitable for cell culture, ≥98%

CAS：24280-93-1

分子式：C17H20O6

分子量：320.3

外观：白色，乳白色粉末

纯度：>；=98％

溶解性：溶于甲醇，乙醇；微溶于醚，氯仿；难溶于苯，甲苯；几乎不溶于冷水。

储存： 4℃保存5年

用途：来源于Penicillium stoloniferum及类似菌株的一类抗生素/抗菌药。能在体内通过抑制次黄〔嘌呤核〕苷酸脱氢酶的作用阻断嘌呤核苷酸的合成。阻止T细胞，淋巴细胞的分裂及B细胞中抗体的形成从而作为一种免疫抑制因子。在分子生物学中用于筛选含大肠杆菌黄嘌呤鸟嘌呤磷酸核糖转移酶基因的细胞。

参考资料：

霉酚酸

M3536-50MG 981.63 SIGMA原装北京现货销售
M3536-250MG 3,383.64 SIGMA原装北京现货销售

别名: 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid，麦可酚酸
溶解：
methanol: soluble50 mg/mL (Stock solutions should be stored at 2-8°C.)

Application

Recommended for use as a selection agent at 25 μg/ml.
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions

Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Immunosuppressive agent. Used to inhibit early stage biosynthesis of purine nucleotides. Used as a specific inhibitor of inosine 5′-monophosphate (IMP) dehydrogenase (IMPDH) and inducer of IMP dehydrogenase gene expression.
Mode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.

霉酚酸;Mycophenolic acid;24280-93-1;M3536;SIGMA