有效抑制剂多肽TPP-1/2426685-25-6/TPP-1

Product Name：TPP-1

CAS No.：2426685-25-6

Synonyms：有效抑制剂多肽TPP-1

Catalog No.：218P432

Brand：Typeptide Biotech（肽研生物）

Description：TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂多肽，序列中含有22个氨基酸。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。TPP-1是通过细菌表面展示鉴定的一种多肽，其特异性结合程序性细胞死亡配体1（PD-L1），并阻断程序性细胞死蛋白1（PD-1）/PD-L1相互作用。TPP-1与游离的PD-L1以及在其细胞膜上表达PD-L1的细胞结合，可以逆转PD-L1介导的对T细胞活化的抑制，并通过T细胞依赖性机制抑制人类肿瘤生长。在异种移植物小鼠模型中，TPP-1处理的小鼠的肿瘤生长比对照组低56%-71%。

TPP-1 is an effective inhibitor peptide of PD-1/PD-L1 interaction, containing 22 amino acids in its sequence. TPP-1 binds specifically to PD-L1 with high affinity (KD=95 nM). In animal models, TPP-1 inhibits tumor growth by reactivating T cell function. TPP-1 is a peptide identified through bacterial surface display, which specifically binds to programmed cell death ligand 1 (PD-L1) and blocks the interaction between programmed cell death protein 1 (PD-1) and PD-L1. TPP-1 binds to free PD-L1 and cells expressing PD-L1 on its cell membrane, which can reverse PD-L1-mediated inhibition of T cell activation and inhibit human tumor growth through T cell dependent mechanisms. In the xenograft mouse model, tumor growth in mice treated with TPP-1 was 56% -71% lower than that in the control group.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。