AZD8797

AZD8797 (also known as KAND567; CAS No. 911715-90-7) is a potent, orally bioavailable small-molecule allosteric antagonist of the chemokine receptor CX3CR1 (Ki ≈ 3.9 nM). It non-competitively blocks CX3CL1/fractalkine-mediated CX3CR1 signaling and shows approximately 700-fold selectivity over CXCR2 (Ki ≈ 2800 nM). AZD8797 is widely used as a research tool to investigate CX3CL1/CX3CR1-mediated immune and inflammatory pathways in cardiovascular, oncological, and neuroinflammatory research. It is supplied as a high-purity research-grade compound (typically >98% by HPLC) and is suitable for in vitro and preclinical laboratory studies.

Research Use Only Statement

This product is intended for laboratory research use only. It is not for human or veterinary use.