化合物 KAND567|T14384|TargetMol
AZD8797
911715-90-7
911715-90-7
¥1090
1mg
起订
¥2380
5mg
起订
¥3970
10mg
起订
上海 更新日期:2024-12-12
产品详情:
- 中文名称:
- 化合物 KAND567
- 英文名称:
- AZD8797
- CAS号:
- 911715-90-7
- 品牌:
- TargetMol
- 产地:
- 美国
- 保存条件:
- store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
- 纯度规格:
- 99.68%
- 产品类别:
- 抑制剂
- 货号:
- T14384
Product Introduction
Bioactivity
Name | AZD8797 |
Description | AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventing worsening of nociceptive sensitization and microglial activation in a migraine model of rats following seizures. |
In vitro | In a flow adhesion assay, AZD8797, with IC50 values of 300 nM in human whole blood (hWB) and 6 nM in a B-lymphocyte cell line, antagonizes the natural ligand fractalkine (CX3CL1). AZD8797 also prevents G-protein activation in a [35S]GTPγS accumulation assay. In a β-arrestin recruitment assay, AZD8797 positively modulates the CX3CL1 response at sub-micromolar concentrations. In equilibrium saturation binding experiments, AZD8797 reduces the maximal binding of 125I-CX3CL1 without affecting Kd[1]. AZD8797 selectively and with high affinity binds to human and rat CX3CR1 (Ki of hCX3CR1, 4 nM; Ki of rCX3CR1, 7 nM, respectively). The equilibrium dissociation constant, KB, demonstrates that AZD8797 is a very potent inhibitor for human CX3CR1 (10 nM). The potency is threefold lower for rat CX3CR1 (29 nM) and decreases even further at mouse CX3CR1 (54 nM)[3]. |
In vivo | Treatment with AZD8797 in Dark Agouti rats with myelin oligodendrocyte glycoprotein-induced EAE results in reduced paralysis, CNS pathology, and incidence of relapses. The compound is effective both when starting treatment before onset and after the acute phase[3]. |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (247.79 mM) |
Keywords | AZD 8797 | AZD8797 | AZD-8797 |
Inhibitors Related | Nicotinamide N-oxide | Plerixafor octahydrochloride | Plerixafor | rac-NBI-74330 | LIT927 | Tannic acid | CXCR2-IN-1 | Artemotil | Reparixin | AZD8309 | CXCL-CXCR1/2-IN-1 | Delmetacin |
Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library |
KAND567|||KAN-0440567|TargetMol
公司简介
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。
成立日期 | (12年) |
注册资本 | 566.265100万人民币 |
员工人数 | 100-500人 |
年营业额 | ¥ 1亿以上 |
经营模式 | 贸易,工厂,试剂,定制,服务 |
主营行业 | 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务 |
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