司美诺肽

Product Name：Setmelanotide

CAS No.：920014-72-8；1504602-49-6；2759937-80-7（monoacetate，单醋酸盐）

Synonyms：司美诺肽；IRC-022493；BIM-22493；RM-493

Description：Setmelanotide是一种黑皮质素 4 受体 (MC4R) 激动剂多肽，序列中含有8个氨基酸，肽类的两端均被封闭，序列中含有两个D型的氨基酸。Setmelanotide主要作用于人和大鼠黑皮质素4受体，还是激活MC4R的机制可能与天然配体和第一代合成激动剂不同，研究表明Setmelanotide可能通过拮抗天然存在且抑制MC4R激活的神经递质发挥作用；已经证实Setmelanotide治疗肥胖症效果积极,已达3期临床终点。

Setmelanotide is an MC4R agonist peptide containing 8 amino acids in its sequence, with both ends of the peptide blocked and featuring two D-type amino acids. It primarily acts on the melanocortin 4 receptor in humans and rats, and its mechanism of activating MC4R may differ from that of natural ligands and first-generation synthetic agonists. Research suggests that Setmelanotide may function by antagonizing neurotransmitters that naturally exist and inhibit MC4R activation; clinical studies have confirmed its positive efficacy in treating obesity, achieving phase III clinical endpoints.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H2O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.