PKA抑制剂片段6-22/121932-06-7/PKA Inhibitor Fragment (6-22) amide

Product Name：PKA Inhibitor Fragment (6-22) amide

CAS No.：121932-06-7

Synonyms：PKA抑制剂片段6-22

Catalog No.：198P36

Brand：Typeptide Biotech（肽研生物）

Description：PKA Inhibitor Fragment (6-22) amide是一种 PKA 抑制剂多肽，是由17个氨基酸组成的直链多肽。在细胞生物学中，蛋白激酶 A (PKA) 是一个酶家族，其活性取决于细胞水平的环 AMP (cAMP)。 PKA 也被认为是一种 cAMP 依赖性蛋白激酶。 PKA在细胞中具有多种功能，例如调节糖、糖原和脂质代谢，在体外能与 (Ala)Kemptide 相比，发现 PKA 抑制剂片段 (6-22) 酰胺在抑制效力方面具有显着差异，这可能是由于几个非精氨酸残基对这种效力差异的关键作用。以高效力抑制 CAMP 依赖性蛋白激酶的 PKA 抑制剂片段 (6-22) 的最小长度类似物是 17 个残基 PKI-(6-22)-酰胺。 PKA 抑制剂片段 (6-22) 在活性位点的肽/蛋白质结合部分以低纳摩尔 Ki 值的竞争方式相互作用。为了抑制 CAMP 依赖性蛋白激酶，PKA 抑制剂片段 (6-22) 需要假底物位点（残基 14-22）和残基 6-13 内的其他 NH2 末端决定簇。 PKA 抑制剂片段 (6-22) 可以清除与活性位点的结合区相互作用的模拟蛋白和肽底物，特别是在 COOH 末端假底物碱性域中。毫无疑问，PKA抑制剂片段（6-22）的整体亲和力是由于氢键的数量以及与CAMP依赖性蛋白激酶活性位点的其他键相互作用。

The PKA inhibitor fragment (6-22) amide is a PKA inhibitor peptide consisting of a straight-chain polypeptide with 17 amino acids. In cell biology, protein kinase A (PKA) is an enzyme family whose activity depends on the cellular levels of cyclic AMP (cAMP). PKA is also considered a cAMP-dependent protein kinase. PKA has various functions in cells, such as regulating glucose, glycogen, and lipid metabolism. In vitro, compared to (Ala)Kemptide, PKA inhibitor fragment (6-22) amide exhibits significant differences in inhibitory potency, likely due to the critical role of several non-arginine residues in this potency variation. The minimal-length analog of PKA inhibitor fragment (6-22) with high potency against cAMP-dependent protein kinase is the 17-residue PKI-(6-22)-amide. PKA inhibitor fragment (6-22) interacts in a competitive manner with the peptide/protein binding region of the active site at low nanomolar Ki values. To inhibit cAMP-dependent protein kinase, PKA inhibitor fragment (6-22) requires a pseudosubstrate site (residues 14-22) and other NH2-terminal determinants within residues 6-13. PKA inhibitor fragment (6-22) can displace analogs of protein and peptide substrates that interact with the binding region of the active site, particularly in the COOH-terminal pseudosubstrate basic domain. Undoubtedly, the overall affinity of PKA inhibitor fragment (6-22) stems from the number of hydrogen bonds and other interactions with the active site of cAMP-dependent protein kinase.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。