抑制剂121932-06-7PKA Inhibitor Fragment (6-22) amide

Product Name：PKA Inhibitor Fragment (6-22) amide

CAS No.：121932-06-7

Synonyms：PKA抑制剂片段6-22

Catalog No.：198P36

Brand：HongTide（上海鸿肽生物）

Description：PKA Inhibitor Fragment (6-22) amide是一种 PKA 抑制剂多肽，是由17个氨基酸组成的直链多肽。在细胞生物学中，蛋白激酶 A (PKA) 是一个酶家族，其活性取决于细胞水平的环 AMP (cAMP)。 PKA 也被认为是一种 cAMP 依赖性蛋白激酶。 PKA在细胞中具有多种功能，例如调节糖、糖原和脂质代谢，在体外能与 (Ala)Kemptide 相比，发现 PKA 抑制剂片段 (6-22) 酰胺在抑制效力方面具有显着差异，这可能是由于几个非精氨酸残基对这种效力差异的关键作用。以高效力抑制 CAMP 依赖性蛋白激酶的 PKA 抑制剂片段 (6-22) 的最小长度类似物是 17 个残基 PKI-(6-22)-酰胺。 PKA 抑制剂片段 (6-22) 在活性位点的肽/蛋白质结合部分以低纳摩尔 Ki 值的竞争方式相互作用。为了抑制 CAMP 依赖性蛋白激酶，PKA 抑制剂片段 (6-22) 需要假底物位点（残基 14-22）和残基 6-13 内的其他 NH2 末端决定簇。 PKA 抑制剂片段 (6-22) 可以清除与活性位点的结合区相互作用的模拟蛋白和肽底物，特别是在 COOH 末端假底物碱性域中。毫无疑问，PKA抑制剂片段（6-22）的整体亲和力是由于氢键的数量以及与CAMP依赖性蛋白激酶活性位点的其他键相互作用。

PKA Inhibitor Fragment (6-22) amide is a PKA inhibitor peptide composed of 17 amino acids in a straight chain. In cellular biology, protein kinase A (PKA) is a family of enzymes whose activity depends on the cyclic AMP (cAMP) at the cellular level. PKA is also considered a cAMP dependent protein kinase. PKA has multiple functions in cells, such as regulating sugar, glycogen, and lipid metabolism. In vitro, compared with (Ala) Kemptide, the PKA inhibitor fragment (6-22) amide showed significant differences in inhibitory efficacy, which may be due to the key role of several non arginine residues in this difference in potency. The minimum length analog of the PKA inhibitor fragment (6-22) that inhibits CAMP dependent protein kinases with high potency is 17 residues of PKI - (6-22) - amide. The peptide/protein binding part of the PKA inhibitor fragment (6-22) at the active site interacts in a competitive manner with a low nanomolar Ki value. In order to inhibit CAMP dependent protein kinase, the PKA inhibitor fragment (6-22) requires a pseudo substrate site (residues 14-22) and other NH2 terminal determinants within residues 6-13. The PKA inhibitor fragment (6-22) can clear the mimic protein and peptide substrate interacting with the binding region of the active site, especially in the basic domain of the false substrate at the COOH end. There is no doubt that the overall affinity of the PKA inhibitor fragment (6-22) is due to the number of hydrogen bonds and the interaction with other bonds at the active site of the CAMP dependent protein kinase.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

上海鸿肽生物科技有限公司

手机： +86-18018095145 （同微信号）

QQ: 3259098395

邮箱：sales1@hongtide.com