(S)-5-(2,2-二甲基四氢-2H-吡喃-4-基)-N-甲基-N-苯基-1H-吲哚-2-甲酰胺

产品名称：多替诺雷

CAS号：1285572-51-1

化学名：(3,5-二氯-4-羟苯基)(1,1-二氧-1,2-二氢-3H-1λ⁶-1,3-苯并噻唑-3-基)甲酮

分子量：358.20

性状：白色至淡黄白色固体粉末；难溶于甲醇、乙醇，几乎不溶于水。

药物类别：抗痛风药，高选择性URAT1抑制剂，促尿酸排泄类降尿酸药物，不属于抗生素。

用途：原料药用于痛风伴高尿酸血症治疗，通过选择性抑制肾脏URAT1转运蛋白，减少肾小管尿酸重吸收，促进尿酸排泄以降低血尿酸；对照品用于原料药及制剂有关物质检测、分析方法开发与验证、强制降解试验、杂质谱研究。科研对照品仅用于实验室研究，不可直接用于人体。

保存条件：密封，遮光，≤25℃保存，防潮；对照品2～8℃密封避光干燥保存，长期保存建议-20℃，避光，避免反复冻融。

结构确认：¹H-NMR、MS确证结构，HPLC检测纯度。

英文 Description

Product Name: Dotinurad

CAS No.：1285572-51-1

Chemical Name: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone

Molecular Weight: 358.20

Appearance: White to pale yellowish-white solid powder. Slightly soluble in methanol and ethanol, practically insoluble in water.

Drug Class: Anti-gout agent, highly selective URAT1 inhibitor, uricosuric agent, not an antibiotic.

Application: Active pharmaceutical ingredient for the treatment of gout with hyperuricemia. It selectively inhibits renal URAT1 transporter to reduce tubular reabsorption of uric acid and promote uric acid excretion, thereby decreasing serum uric acid level. The reference standard is used for related substances test, analytical method development & validation, forced degradation and impurity profile study. For research use only, not for human use.

Storage: Store tightly closed, protected from light at temperature not exceeding 25°C, keep dry. For reference standard: store at 2–8°C; long-term storage at -20°C, protected from light, avoid repeated freeze-thaw cycles.