ARV-825

ARV-825 is a potent PROTAC-based targeted protein degrader designed to induce the selective degradation of BET (bromodomain and extraterminal) proteins , particularly BRD4 . It functions by recruiting BRD4 to the cereblon (CRBN) E3 ubiquitin ligase , promoting ubiquitination and subsequent degradation of the target protein through the ubiquitin–proteasome system .

ARV-825 is widely used as a research tool in targeted protein degradation, epigenetic regulation, cancer biology, and drug discovery . Its ability to reduce intracellular BRD4 levels makes it useful for investigating BET-dependent signaling pathways and evaluating therapeutic strategies based on targeted protein degradation.

Product Information:

• CAS No.: 1818885-28-7

• Molecular Formula: C₄₆H₄₇ClN₈O₉S

• Molecular Weight: 923.43 g/mol

• Category: PROTAC / Targeted Protein Degrader

• Target: BRD4 / BET proteins

• E3 Ligase: Cereblon (CRBN)

• Research Areas: Cancer research, epigenetics, targeted protein degradation, drug discovery