Thalidomide-O-PEG4-Boc

Thalidomide-O-PEG4-Boc (CAS No. 2411681-87-1) is a synthesized E3 ligase ligand-linker conjugate consisting of a thalidomide-based cereblon (CRBN) ligand and a PEG4 linker with a terminal Boc-protected functional group. The compound is designed as a building block for PROTAC (Proteolysis Targeting Chimera) development, where the thalidomide moiety can recruit the CRBN E3 ubiquitin ligase and the PEG4 linker provides a spacer for conjugation to a target protein ligand.

Thalidomide-O-PEG4-Boc is particularly useful for the synthesis and optimization of CRBN-recruiting PROTAC molecules and other targeted protein degradation compounds. The terminal Boc protecting group can be removed during subsequent synthetic steps to enable further functionalization and coupling with a target-binding ligand.

Molecular Formula: C₂₈H₃₈N₂O₁₁
Molecular Weight: 578.61 g/mol
CAS No.: 2411681-87-1
Chemical Name: tert-butyl 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12-tetraoxapentadecan-15-oate

Applications: PROTAC development; CRBN-mediated targeted protein degradation; E3 ligase ligand-linker synthesis; medicinal chemistry; chemical biology research.